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房雷副教授
 
发布时间: 2017-10-09         浏览次数: 13


【个

·姓名:房雷

·性别:男

·出生年月:1979.10

·民族:汉

·职称:副教授

·学历:博士

·联系电话:13776633178

·电子信箱:lei.fang@seu.edu.cn

课题组网址:http://pcseu.gotoip2.com/index.html

【研究方向

靶向抗肿瘤药物及载体材料研究

多功能抗阿尔茨海默病药物研究


1998.9-2002.7

中国药科大学化学制药专业,获学士学位

2002.9-2005.7

中国药科大学,药物化学专业,硕博连读硕士研究生阶段

2005.7

获得德意志学术交流中心DAAD Sandwich”奖学金

2005.9-2006.7

同济大学留德预备部,获中级德语证书

2008.6-2008.10

Friedrich-Schiller-Universität Jena, 博士研究(与中国药科大学联合培养)086月于中国药科大学获博士学位

2009.1-2011.10

东南大学药物研究中心江苏省生物药物高技术研究重点实验室,讲师

2011.10-2012.3

获得德国洪堡奖学金(Alexander von Humboldt Foundation),洪堡访问学者

2015.4-至今

东南大学药物研究中心江苏省生物药物高技术研究重点实验室,副教授

科研项目

1项目类别及编号:主持1项国家自然科学基金青年科学基金项目 (No. 81001361)名称:新型2,5,8-三取代二苯并呋喃及其NO供体偶联物的构建及抗AD活性研究;研究起止年月2011.01-2013.12资助金额17万;进展情况已结题

2项目类别及编号:主持博士点基金青年教师项目(No. 20100092120046)名称:新型肝靶向醌甲基前体型姜黄素衍生物的构建及抗肿瘤活性研究;研究起止年月2011.01-2013.12资助金额3.6万;进展情况已结题

3项目类别及编号:主持江苏省自然科学基金面上项目(No. BK20151402)名称杂合交联型肿瘤靶向胶束给药系统的设计、合成及构效关系研究研究起止年月2015.07-2018.06资助金额10万;进展情况正在进行。



论文及获奖

发表论文:

2016

  1. Fang L(房雷), Feng M, Chen F, Liu X, Shen H, Zhao J, Gou S. Oleanolic acid-NO donor-platinum(II) trihybrid molecules: Targeting cytotoxicity on hepatoma cells with combined action mode and good safety.Bioorg Med Chem,2016, 24(19):4611-4619.

  2. Fang L(房雷), Chen M, Liu Z, Fang X, Gou S, Chen L.Ferulic acid-carbazole hybrid compounds: Combination of cholinesterase inhibition, antioxidant and neuroprotection as multifunctional anti-Alzheimer agents.Bioorg Med Chem,2016, 24(4): 886-893.

  3. Wang Z, Yu H, Gou S, Chen F, Fang L(房雷,通讯作者). Design, Synthesis, and Biological Features of Platinum(II) Complexes with Rigid Steric Hindrance.Inorg Chem,2016, 55(9):4519-4528.

  4. Yu H, Gou S, Wang Z, Chen F, Fang L(房雷,通讯作者).Toward overcoming cisplatin resistance via sterically hindered platinum(II) complexes.Eur J Med Chem,2016, 114:141-152.

  5. Lyu A, Qin X,Fang L(房雷,通讯作者), Gou S. Synthesis, cytotoxicity, and interaction with DNA of platinum(II) complexes of (1R,2R)N12amyl1,2diaminocyclohexane. J Coord Chem, 2016, 69(10):1653–1662.

  6. Zhao J(并列第一作者), Fang L(房雷,并列第一作者), Zhang X, Liang Y, Gou S.Synthesis and biological evaluation of new [1,2,4]triazolo[4,3-a]pyridine derivatives as potential c-Met inhibitors.Bioorg Med Chem, 2016, 24(16):3483-3493.


2015

  1. Liu F, Gou S, Chen F, Fang L(房雷,通讯作者), Zhao J.Study on Antitumor Platinum(II) Complexes of Chiral Diamines with Dicyclic Species as Steric Hindrance. J Med Chem, 2015, 58(16): 6368-6377.

  2. Lyu A(并列第一作者), Fang L(房雷,并列第一作者), Gou S, Liu X. Design, Synthesis and Biological Evaluation of Lapatinib Derivatives as HER1/HER2 Inhibitors. Lett DrugDesDiscov, 2015, 12(7): 574­584.


2014

  1. Fang L(房雷), Wang M,Gou S, Liu X, Zhang H, Cao F.Combination of Amino Acid/Dipeptide with Nitric Oxide-donating Oleanolic Acid Derivatives as PepT1 Targeting Antitumor Prodrugs. J Med Chem, 2014, 57(3):1116-1120.

  2. Fang L(房雷), Fang X, Gou S, Lupp A, Lenhardt I, Sun Y, Huang Z, Chen Y, Cheng L, Zhang Y, Fleck C. Design, synthesis and biological evaluation of D-ring openedgalantamine analogs as multifunctional anti-Alzheimer agents. Eur J Med Chem, 2014, 76:376-386.

  3. Fang L(房雷), Gou S, Liu X, Cao F, Cheng L.Design, synthesis and anti-Alzheimer properties of dimethylaminomethyl-substituted curcumin derivatives. Bioorg Med Chem Lett,2014, 24(1):40-43.

  4. Fang L(房雷), Zhang H, Fang X, Gou S, Cheng L. Preparation of carbazole and dibenzofuran derivatives by selective bromination on aromatic rings or benzylic groups with N-bromosuccinimide. Indian J Chem B, 53(5): 635-641.

  5. Lyu A(并列第一作者), Fang L(房雷,并列第一作者), Gou S. Design and synthesis of Lapatinib derivatives containing a branched side chain as HER1/HER2 targeting antitumor drug candidates. Eur J Med Chem, 2014, 87:631-642.


2013

  1. Fang L(房雷), Gou S, Zhao J, Sun Y, Cheng L.Platinum(II) complexes with N-monoalkyl 1R,2R-diaminocyclohexane derivatives as carrierligands and 3-hydroxycyclobutane-1,1-dicarboxylate as a leaving group: potent cytotoxicity and DNAbinding ability. Eur J Med Chem,2013, 69:842-847.

  2. Fang L(房雷), Gou S, Fang X, Cheng L, Fleck C.Current progresses of novel natural products and their derivatives/analogues as anti-Alzheimer candidates: an update.Mini Rev Med Chem,2013, 13(6):870-887.

  3. Cao F, Gao Y, Wang M, Fang L(房雷,通讯作者), Ping Q.Propylene glycol-Linked Amino Acid/Dipeptide Diester Prodrugs of Oleanolic Acid for PepT1-Mediated Transport: Synthesis, Intestinal Permeability and Pharmacokinetics. Mol Pharmaceut, 2013, 10(4):1378-1387.

  4. Fang X, Fang L(房雷,通讯作者), Gou S, Cheng L.Design and synthesis of dimethylaminomethyl-substituted curcumin derivatives/analogues: Potent antitumor and antioxidant activity, improved stability and aqueous solubility compared with curcumin.Bioorg Med Chem Lett,2013, 23(5):1297-1301.


2012

  1. Sun Y, Liu F, Gou S, Cheng L, Fang L (房雷,通讯作者), Yin R. Synthesis and in vitro antiproliferative activity of platinum(II) complexes withN-monoalkyl 1R,2R-diaminocyclohexane as ligands. Eur J Med Chem,2012,55:297-306.

  2. Fang X,Fang L(房雷,通讯作者), Gou S. Progresses in synthetic methods of carbazole and its derivatives. Chin J Org Chem, 2012, 32(7): 1217-1231.


2011

  1. Fang L(房雷), Gou S, Zhang Y. Progresses in Total Synthesis of Galantamine. Chin J Org Chem,2011,31(3):286-296.


2010

  1. Fang L(房雷),Jumpertz S, Zhang Y, Appenroth D, Fleck C, Mohr K, Tränkle C, Decker M. Hybrid molecules from xanomeline and tacrine: enhanced tacrine actions on cholinesterases and muscarinic M1 receptors. J Med Chem,2010, 53(5): 2094-2103.


2008

  1. Fang L(房雷), Appenroth D, Decker M, Kiehntopf M, Roegler C, Deufel T, Fleck C, Peng, S, Zhang Y, Lehmann J. Synthesis and biological evaluation of NO-donor-tacrine hybrids as hepatoprotective anti-Alzheimer drug candidates. J Med Chem,2008, 51(4): 713-716.   

  2. Fang L(房雷), Appenroth D, Decker M, Kiehntopf M, Lupp A, Peng S, Fleck C, Zhang Y, Lehmann J. NO-donating tacrine derivatives improve scopolamine-induced cognition impairment and show less hepatotoxicity. J Med Chem,2008, 51(24): 7666-7669.

  3. Fang L(房雷), Lehmann J. NO donor hybrid compounds as multifunctional therapeutic agents. Expert Opin Ther Pantents,2008, 18(10):1111-1125.

  4. Fang L(房雷), Kraus B, Lehmann J, Heilmann J, Zhang Y, Decker M. Design and synthesis of tacrine-ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates. Bioorg Med Chem Lett,2008, 18(9):2905-2909.

  5. Fang L(房雷), Huang Z, Zhang Y, Ji H, Ding D. Synthesis, anti-inflammatory activity and safety of hydrocortisone derivatives coupled with furoxans and nitrates. Chin J Org Chem,2008,28(5):841-850.


2007

  1. Fang L(房雷), Zhang Y, Lehmann J, Wang Y, Ji H, and Ding D. Design and synthesis of furoxan-based nitric oxide-releasing glucocorticoid derivatives with potent anti-inflammatory activity and improved safety. Bioorg Med Chem Lett, 2007, 17(4):1062-1066.


发明专利:

申请国家发明专利7,已获授权4


获奖情况:


2009年江苏省优秀博士论文(导师:张奕华教授)


2010年全国优秀博士论文提名奖(导师:张奕华教授)


2011-2012获德国洪堡基金资助


2016年获第十届世界华人药物化学研讨会“优秀青年学者”称号


英文简历


PersonalInformation

·Name: Lei Fang

·Gender: male

·Date of Birth: 1979.10

·Nationality: Chinese

·Title: Dr.

·Degree: doctor

·Tel: 025-83272381

·Email: lei.fang@seu.edu.cn

Research

My current research interests focus on:

  1. Tumor targeting anti-tumor drugs and carrier materials

  2. Multi-functional anti-Alzheimer drugs


Educational and Professional Experience

Education

Aug. 2006------Sep. 2008: Friedrich-Schiller-University Jena

Jena, Germany

Specialty: Medicinal Chemistry

Ph.D.Awarded in 2008


Sep. 2005------Jun. 2006: Tongji University  

Shanghai, P. R. China

One year German language training


Sep. 2002------Jun. 2005: China Pharmaceutica University,

Nanjing, P. R. China

Specialty: Medicinal Chemistry

Master-to-Doctor candidate


Sep. 1998------Jul. 2002: China Pharmaceutical University      

Nanjing, P. R. China

Specialty: Pharmaceutical Engineering

Bachelor of Engineering Awarded in 2002

Professional Experience

Jan. 2009------Oct. 2011: Lecturer in Medicinal Chemistry

Pharmaceutical research center, Jiangsu Province Hi-Tech Key Laboratory for Bio-medical Research, Southeast University

Nanjing, P. R. China


Oct. 2011------Mar. 2012: Alexander von Humboldt Fellow

Friedrich-Schiller-University Jena

Jena, Germany


Mar. 2012------present: Lecturer in Medicinal Chemistry

Pharmaceutical research center, Jiangsu Province Hi-Tech Key Laboratory for Bio-medical Research, Southeast University

Nanjing, P. R. China

Grant Activities

  1. National Natural Science Foundation of China (project No. 81001361)

  2. Ph.D. Programs Foundation of Ministry of Education of China (project No. 20100092120046)


Publications and Awards

2016

  1. Fang L(房雷), Feng M, Chen F, Liu X, Shen H, Zhao J, Gou S. Oleanolic acid-NO donor-platinum(II) trihybrid molecules: Targeting cytotoxicity on hepatoma cells with combined action mode and good safety.Bioorg Med Chem,2016, 24(19):4611-4619.

  2. Fang L(房雷), Chen M, Liu Z, Fang X, Gou S, Chen L.Ferulic acid-carbazole hybrid compounds: Combination of cholinesterase inhibition, antioxidant and neuroprotection as multifunctional anti-Alzheimer agents.Bioorg Med Chem,2016, 24(4): 886-893.

  3. Wang Z, Yu H, Gou S, Chen F, Fang L(房雷,通讯作者). Design, Synthesis, and Biological Features of Platinum(II) Complexes with Rigid Steric Hindrance.Inorg Chem,2016, 55(9):4519-4528.

  4. Yu H, Gou S, Wang Z, Chen F, Fang L(房雷,通讯作者).Toward overcoming cisplatin resistance via sterically hindered platinum(II) complexes.Eur J Med Chem,2016, 114:141-152.

  5. Lyu A, Qin X,Fang L(房雷,通讯作者), Gou S. Synthesis, cytotoxicity, and interaction with DNA of platinum(II) complexes of (1R,2R)N12amyl1,2diaminocyclohexane. J Coord Chem, 2016, 69(10):1653–1662.

  6. Zhao J(并列第一作者), Fang L(房雷,并列第一作者), Zhang X, Liang Y, Gou S.Synthesis and biological evaluation of new [1,2,4]triazolo[4,3-a]pyridine derivatives as potential c-Met inhibitors.Bioorg Med Chem, 2016, 24(16):3483-3493.


2015

  1. Liu F, Gou S, Chen F, Fang L(房雷,通讯作者), Zhao J.Study on Antitumor Platinum(II) Complexes of Chiral Diamines with Dicyclic Species as Steric Hindrance. J Med Chem, 2015, 58(16): 6368-6377.

  2. Lyu A(并列第一作者), Fang L(房雷,并列第一作者), Gou S, Liu X. Design, Synthesis and Biological Evaluation of Lapatinib Derivatives as HER1/HER2 Inhibitors. Lett DrugDesDiscov, 2015, 12(7): 574­584.


2014

  1. Fang L(房雷), Wang M,Gou S, Liu X, Zhang H, Cao F.Combination of Amino Acid/Dipeptide with Nitric Oxide-donating Oleanolic Acid Derivatives as PepT1 Targeting Antitumor Prodrugs. J Med Chem, 2014, 57(3):1116-1120.

  2. Fang L(房雷), Fang X, Gou S, Lupp A, Lenhardt I, Sun Y, Huang Z, Chen Y, Cheng L, Zhang Y, Fleck C. Design, synthesis and biological evaluation of D-ring openedgalantamine analogs as multifunctional anti-Alzheimer agents. Eur J Med Chem, 2014, 76:376-386.

  3. Fang L(房雷), Gou S, Liu X, Cao F, Cheng L.Design, synthesis and anti-Alzheimer properties of dimethylaminomethyl-substituted curcumin derivatives. Bioorg Med Chem Lett,2014, 24(1):40-43.

  4. Fang L(房雷), Zhang H, Fang X, Gou S, Cheng L. Preparation of carbazole and dibenzofuran derivatives by selective bromination on aromatic rings or benzylic groups with N-bromosuccinimide. Indian J Chem B, 53(5): 635-641.

  5. Lyu A(并列第一作者), Fang L(房雷,并列第一作者), Gou S. Design and synthesis of Lapatinib derivatives containing a branched side chain as HER1/HER2 targeting antitumor drug candidates. Eur J Med Chem, 2014, 87:631-642.


2013

  1. Fang L(房雷), Gou S, Zhao J, Sun Y, Cheng L.Platinum(II) complexes with N-monoalkyl 1R,2R-diaminocyclohexane derivatives as carrierligands and 3-hydroxycyclobutane-1,1-dicarboxylate as a leaving group: potent cytotoxicity and DNAbinding ability. Eur J Med Chem,2013, 69:842-847.

  2. Fang L(房雷), Gou S, Fang X, Cheng L, Fleck C.Current progresses of novel natural products and their derivatives/analogues as anti-Alzheimer candidates: an update.Mini Rev Med Chem,2013, 13(6):870-887.

  3. Cao F, Gao Y, Wang M, Fang L(房雷,通讯作者), Ping Q.Propylene glycol-Linked Amino Acid/Dipeptide Diester Prodrugs of Oleanolic Acid for PepT1-Mediated Transport: Synthesis, Intestinal Permeability and Pharmacokinetics. Mol Pharmaceut, 2013, 10(4):1378-1387.

  4. Fang X, Fang L(房雷,通讯作者), Gou S, Cheng L.Design and synthesis of dimethylaminomethyl-substituted curcumin derivatives/analogues: Potent antitumor and antioxidant activity, improved stability and aqueous solubility compared with curcumin.Bioorg Med Chem Lett,2013, 23(5):1297-1301.


2012

  1. Sun Y, Liu F, Gou S, Cheng L, Fang L (房雷,通讯作者), Yin R. Synthesis and in vitro antiproliferative activity of platinum(II) complexes withN-monoalkyl 1R,2R-diaminocyclohexane as ligands. Eur J Med Chem,2012,55:297-306.

  2. Fang X,Fang L(房雷,通讯作者), Gou S. Progresses in synthetic methods of carbazole and its derivatives. Chin J Org Chem, 2012, 32(7): 1217-1231.


2011

  1. Fang L(房雷), Gou S, Zhang Y. Progresses in Total Synthesis of Galantamine. Chin J Org Chem,2011,31(3):286-296.


2010

  1. Fang L(房雷),Jumpertz S, Zhang Y, Appenroth D, Fleck C, Mohr K, Tränkle C, Decker M. Hybrid molecules from xanomeline and tacrine: enhanced tacrine actions on cholinesterases and muscarinic M1 receptors. J Med Chem,2010, 53(5): 2094-2103.


2008

  1. Fang L(房雷), Appenroth D, Decker M, Kiehntopf M, Roegler C, Deufel T, Fleck C, Peng, S, Zhang Y, Lehmann J. Synthesis and biological evaluation of NO-donor-tacrine hybrids as hepatoprotective anti-Alzheimer drug candidates. J Med Chem,2008, 51(4): 713-716.   

  2. Fang L(房雷), Appenroth D, Decker M, Kiehntopf M, Lupp A, Peng S, Fleck C, Zhang Y, Lehmann J. NO-donating tacrine derivatives improve scopolamine-induced cognition impairment and show less hepatotoxicity. J Med Chem,2008, 51(24): 7666-7669.

  3. Fang L(房雷), Lehmann J. NO donor hybrid compounds as multifunctional therapeutic agents. Expert Opin Ther Pantents,2008, 18(10):1111-1125.

  4. Fang L(房雷), Kraus B, Lehmann J, Heilmann J, Zhang Y, Decker M. Design and synthesis of tacrine-ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates. Bioorg Med Chem Lett,2008, 18(9):2905-2909.

  5. Fang L(房雷), Huang Z, Zhang Y, Ji H, Ding D. Synthesis, anti-inflammatory activity and safety of hydrocortisone derivatives coupled with furoxans and nitrates. Chin J Org Chem,2008,28(5):841-850.


2007

  1. Fang L(房雷), Zhang Y, Lehmann J, Wang Y, Ji H, and Ding D. Design and synthesis of furoxan-based nitric oxide-releasing glucocorticoid derivatives with potent anti-inflammatory activity and improved safety. Bioorg Med Chem Lett, 2007, 17(4):1062-1066.



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