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赵健
 
发布时间: 2017-10-09         浏览次数: 13


【个

·姓名:赵健

·性别:男

·出生年月:1986.10

·民族:汉

·职称:讲师

·学历:博士

·联系电话:15151854048

·电子信箱:zhaojianzhaokuan@163.com

课题组网址:http://pcseu.gotoip2.com/index.html

【研究方向

抗肿瘤药物的研究

金属药物的反应动力学及其理论计算

2004.9 ­~ 2008.6     郑州大学应用化学(基地班)专业,理学学士学位

2008.9 ~ 2014.6     东南大学制药工程专业,获工学博士学位

2014.10 ~ 2015.10   加拿大Simon Fraser University博士后

2015.11-至今       东南大学讲师

科研项目

  1. 项目类别及编号:主持1项国家自然科学基金青年科学基金项目 (No. 21601034)名称基于甘露糖靶向的糖受体类铂抗肿瘤配合物的研究研究起止年月2017.01-2019.12资助金额进展情况正在进行

  2. 项目类别及编号:主持1项江苏省自然科学基金青年项目(No.BK20160664)名称基于三乙基苯类甘露糖受体的金属配合物的构建及生物学评价研究起止年月2016.07-2019.06资助金额进展情况正在进行。

  3. 项目类别及编号:东南大学新进教师人才引进启动费(No.1107047109;研究起止年月:2016.01-2016.12;资助金额;进展情况:正在进行。

论文及获奖

代表论文

  1. Jian Zhao, Zhichen Xu, Jing Lin, Shaohua Gou. Exploring the Hydrolytic Behavior of the Platinum(IV) Complexes with Axial Acetato Ligands. Inorg. Chem., 2017, 56, 9851-9859.

  2. Jian Zhao, Dan Wang, Gang Xu, Shaohua Gou. Improve the anticancer potency of the platinum(II) complexes through functionalized leaving group. J. Inorg. Biochem., 2017, 175, 20-28.

  3. Zichen Xu, Jian Zhao (Equal Contribution), Shaohua Gou, Gang Xu. Novel hypoxia-targeting Pt(IV) prodrugs. ChemComm., 2017, 53, 3749-3752.

  4. Jian Zhao, Kathleen E. Prosser, Stephanie W. Chang, Shradha P. Zakharia and Charles J. Walsby. Combining a Ru(II)-arene complex with a NO-releasing nitrate-ester ligand generates cytotoxic activity. Dalton Trans., 2016, 45, 18079–18083.

  5. Jian Zhao, Shaohua Gou, Fengfan Liu. Potent Anticancer Activity and Possible Low Toxicity of Platinum(II) Complexes with Functionalized 1,1-Cyclobutanedicarboxylate as a Leaving Ligand. Chem. Eur. J. 2014, 20, 15216-15225.

  6. Jian Zhao, Shaohua Gou, Gang Xu, Lin Cheng. Antitumor platinum(II) complexes of N-monoalkyl 1R,2R-diaminocyclohexanes with 3-(nitrooxy)cyclobutane-1,1-dicarboxylate as a leaving group. Eur. J. Med. Chem. 2014, 85, 408-417.

  7. Jian Zhao, Shaohua Gou, Gang Xu. Synthesis and biological evaluation of mixed ammine/amine platinum(II) complexes with dicarboxylate containing organic nitrate as ligand. Inorg. Chim. Acta. 2014, 409, 310-314.

  8. Jian Zhao, Shaohua Gou, Yanyan Sun, Lei Fang, Zhimei Wang. Antitumor platinum(II) complexes containing platinum-based moieties of present platinum drugs and furoxan groups as nitric oxide donors: synthesis, DNA interaction, and cytotoxicity. Inorg. Chem. 2012, 51, 10317-10324.

  9. Jian Zhao, Shaohua Gou, Fei Liu, Yanyan Sun, Chuanzhu Gao. Anticancer potency of platinum(II) complexes containing both chloride anion and chelated carboxylate as leaving groups. Inorg. Chem. 2013, 52, 8163-8170.

  10. Jian Zhao, Shaohua Gou, Yanyan Sun, Runting Yin, Zhimei Wang, Nitric oxide donor-based platinum complexes as potential anticanceragents. Chem.Eur. J. 2012, 18, 14276-14281.




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