doi:10.16597/j.cnki.issn.1002-154x.2024.01.007
5-甲基-7-甲氧基异黄酮绿色合成工艺研究
吴可军1,2 张鑫2 岑坚2 唐伟2 钱洪胜1,2∗
(1. 浙江省精细化工超临界反应工程技术研究中心,绍兴 312500; 2. 浙江新和成股份有限公司,绍兴 312500)
Study on Environment-Friendly Synthesis Process of 5-Methyl-7-Methoxyisoflavone
Wu Kejun 1,2 Zhang Xin 1 Cen Jian 2 Tang Wei 2 Qian Hongsheng 1,2∗
(1. The Zhejiang Research Centre of Fine Chemical Supercritical Reaction Engineering and Technology, Shaoxing 312500, China; 2. Zhejiang NHU Co. , Ltd. , Shaoxing 312500, China)
摘要:
以 3,5-二羟基甲苯为原料,经 Hoesch 反应得到 2,4-二羟基-6-甲基脱氧安息香,再经环合反应得到 5-甲 基-7-羟基异黄酮,使用绿色合成试剂碳酸二甲酯经甲氧基化反应得到 5-甲基-7-甲氧基异黄酮,并获得最佳工艺条件,最优条件下三步反应总收率达 47.8%。
关键词：5-甲基-7-羟基异黄酮 5-甲基-7-甲氧基异黄酮 合成；
Abstract：
2,4-dihydroxy-6-methyldeoxybenzoin was synthesized from 3,5-dihydroxy-toluene by Hoesch reaction, then get 5-methyl -7-hydroxyisoflavone via cyclization process. Further preparation of 5-methyl -7-methoxyisoflavone by methoxylation of dimethyl carbonate. The total yield under the optimum production conditions was about 47. 8%.
Keywords：5-methyl-7-hydroxyisoflavone; 5-methyl-7-methoxyisoflavone; synthesis;