黄芩苷联合紫杉醇抑制胃癌细胞增殖的研究

doi:10.16597/j.cnki.issn.1002-154x.2022.03.002

黄芩苷联合紫杉醇抑制胃癌细胞增殖的研究

李梁杰¹ 井虹苏³ Byar Shubh Narayan¹ 丁紫涵¹ 张迪¹ 程开²∗

(1. 佳木斯大学研究生院,黑龙江 佳木斯 154007;2. 佳木斯大学附属第一医院,黑龙江 佳木斯 154000; 3. 深圳市龙岗区人民医院,广东 深圳 518111)

Study on the Inhibitory Effect of Baicalin Combined with Paclitaxel on the Proliferation of Gastric Cancer Cells

Li Liangjie¹; Jing Hongsu³; Byar Shubh Narayan¹; Ding Zihan¹; Zhang Di¹; Cheng Kai²∗;

(1. Graduate School of Jiamusi University, Heilongjiang Jiamusi 154007; 2. The First Affiliated Hospital of Jamusi University, Heilongjiang Jiamusi 154000; 3. Shenzhen Longgang District Peoples-Hospital, Guangdong Shenzhen 518111)

摘要:

选取胃癌 SGC - 7901 细胞,分别用紫杉醇和黄芩苷对其进行作用,MTT 实验检测不同浓度紫杉醇、黄芩苷及两药联合作用 24h 和 48h 的细胞增殖抑制率。 发现紫杉醇和黄芩苷均可抑制 SGC - 7901 细胞生长,并且二者联合作用可提高抑制率,其作用机制可能与 PCNA 蛋白的抑制有关。

关键词：紫杉醇；黄岑苷；胃癌；

Abstract：

Gastric cancer SGC - 7901 cells were treated with paclitaxel and baicalin respectively. MTT assay was used to detect the cell proliferation inhibition rate of paclitaxel, baicalin and the combination of paclitaxel and baicalin for 24 h and 48 h. It was found that both paclitaxel and baicalin could inhibit the growth of SGC – 7901 cells, and the combined effect of paclitaxel and baicalin could increase the inhibition rate. Its mechanism may be related to promoting the expression of apoptotic protein.

Keywords：paclitaxel; baicalin; gastric cancer;