黄酮类化合物抗肝细胞癌 HepG2 细胞系的研究进展

doi:10.16597/j.cnki.issn.1002-154x.2022.12.008

黄酮类化合物抗肝细胞癌 HepG2 细胞系的研究进展

张志强¹ 王琳²∗

(1.佳木斯大学,黑龙江 佳木斯 154007; 2.佳木斯大学附属第一医院,黑龙江 佳木斯 154002)

Research Progress of Flavonoids Against Hepatocellular Carcinoma HepG2 Cell Line

Zhang Zhiqiang¹; Wang Lin²∗;

(1.Jiamusi University, Heilongjiang Jiamusi 154007; 2.The First Affiliated Hospital of Jiamusi University, Heilongjiang Jiamusi 154002)

摘要:

大量研究表明,在肿瘤治疗中,从中药中提取的黄酮类化合物具有抗肿瘤活性,或与化疗药物联合使用可提 高化疗效率。 作者综述了黄酮类化合物诱导的抑制 HepG2 细胞系的细胞内信号通路,介绍了黄酮类化合物抗 HBV/ HCV 活性的研究现状,并对黄酮类化合物在癌症治疗中的应用进行了展望。

关键词：黄酮类化合物；中药；肝细胞癌；HepG2 细胞；

Abstract：

A large number of studies have shown that flavonoids extracted from Traditional Chinese medicine have anti-tumor activity in tumor treatment, or combined with chemotherapy drugs can improve the efficiency of chemotherapy. Flavonoid-induced inhibition of intracellular signaling pathways in HepG2 cell lines was reviewed. The research status of anti-HBV/ HCV activity of flavonoids was introduced, and the application of flavonoids in cancer treatment was prospected.

Keywords：flavonoids; traditional Chinese medicine; hepatocellular carcinoma; HepG2 cells;