苯并吡喃类近红外荧光探针在生物医学中的研究进展

doi:10.16597/j.cnki.issn.1002-154x.2022.02.006

苯并吡喃类近红外荧光探针在生物医学中的研究进展

刘敏¹ 高川¹ 李升²∗

(1.佳木斯大学 临床医学院,黑龙江 佳木斯 154007; 2.佳木斯大学附属第一医院检验科,黑龙江 佳木斯 154007)

Research Progress of Benzopyran-based Near-infrared Fluorescent Probes in Biomedicine

Liu Min¹; Gao Chuan¹; Li Sheng ²∗;

(1. Clinical Medical College of Jiamusi University, Heilongjiang Jiamusi 154007; 2. Department of Laboratory Medicine, The First Affiliated Hospital of Jiamusi University, Heilongjiang Jiamusi 154007)

摘要:

随着荧光染料的不断出现,荧光成像技术得以迅猛发展。 而二氰亚甲基 - 4H - 吡喃( dicyanomethylene - 4H - pyran,DCM)类的荧光染料具有近红外发射、大的斯克托斯位移(Stokes)和光稳定性而得到普遍关注。 而近红外荧 光探针具有显著的红外发射波长、特异性的组织识别、光损伤小、低光漂白及抗荧光背景干扰的特点,特别适合体内的荧光成像。 这篇综述介绍了近几年 DCM 类近红外荧光探针在生物医学中的研究进展,包括对 DCM 结构进行修饰及改造后,使其在疾病的诊断及治疗方面发挥作用,以及对 DCM 近红外荧光探针存在的问题进行的优化,希望促进其在生物医学领域得到进一步的发展。

关键词：苯并吡喃；近红外荧光探针；生物医学；恶性肿瘤；

Abstract：

With the continuous emergence of fluorescent dyes, fluorescent imaging technology has developed rapidly. The dicyanomethylene - 4H - pyran(DCM) type of fluorescent dye has near-infrared emission, large Stokes shift and light stability, and has attracted widespread attention. The near-infrared fluorescent probe has the characteristics of significant infrared emission wavelength, specific tissue recognition, small light damage, low photobleaching and anti-fluorescence background interference, and is particularly suitable for fluorescence imaging in vivo. This review introduces the research progress of DCM-type near-infrared fluorescent probes in biomedicine in recent years. At the same time, the structure of DCM is modified and modified to make it play a role in the diagnosis and treatment of diseases. In addition, optimization of the existing problems of DCM near-infrared fluorescent probes is expected to make it further developed in the field of biomedicine.

Keywords：benzopyrans; near infrared fluorescent probe; biomedicine; malignant tumor;