一锅法制备 3 - 氯丙酰氯

doi:10.16597/j.cnki.issn.1002-154x.2022.04.002

一锅法制备 3 - 氯丙酰氯

吴卫忠¹∗ 蒋燕华²

(1. 常州大学 石油化工学院,江苏 常州 213164;2. 常州寅盛药业有限公司,江苏 常州 213000)

Preparation of 3 - chloropropionyl Chloride by One Pot Method

Wu Weizhong ¹; Jiang Yanhua ²;

(1. School of Petrochemical Engineering, Changzhou University, Jiangsu Changzhou 213164; 2. Changzhou Yincheng Pharmaceutical Co. Ltd. , Jiangsu Changzhou 213000)

摘要:

本文以丙烯酸、三氯化磷和水为原料,一锅法制备 3 - 氯丙酰氯。 加成反应中,反应温度为 70 ~ 80 ℃ ,三氯化磷用量 0.35 ~ 0.4 mol;酰氯化反应中,反应温度为 40 ~ 50 ℃ ,三氯化磷的用量 0.45 mol。 反应收率达到 96.5% 。

关键词：3 - 氯丙酰氯；一锅法；

Abstract：

In this paper, 3 - chloropropionyl chloride was prepared by one pot method with acrylic acid, phosphorus trichloride and water as raw materials. In addition reaction, the reaction temperature is 70 ~ 80 ℃ , the dosage of phosphorus trichloride is 0.35 ~ 0.4 mol; In acyl chlorination, the reaction temperature is 40 ~ 50 ℃ , and the amount of phosphorus trichloride is 0.45mol. The yield was 96.5%.

Keywords：3 - chloropropionyl chloride; one pot method;