doi:10.16597/j.cnki.issn.1002-154x.2023.02.010
阿莫西林燃烧稳定性研究
周利兵∗ 陈琪
(广西科技师范学院,广西 来宾 546199)
Combustion Stability Research of Amoxicillin
Zhou Libing∗; Chen Qi;
(Guangxi Science & Technology Normal University, Guangxi Laibin 546199)
摘要:
作者选择 4 个厂家生成的阿莫西林作为研究对象,利用氧弹量热计测定燃烧热,4 种药品燃烧热大小顺序为:厂家 4 药品 > 厂家 3 药品 > 厂家 1 药品 > 厂家 2 药品。 测试样燃烧热在 9012.70 ~ 20370.59 J·g-1之间,相对标 准偏差(CV) < 5% 。 从热重结果分析,4 种药品燃烧稳定性排序为:厂家 2 药品 > 厂家 1 药品 > 厂家 3 药品 > 厂家 4 药品。 根据熵聚类将不同厂家 4 种药品分为三大类。 作者建立了阿莫西林的多指标综合评价体系,为药物燃烧稳定 性研究提供依据。
关键词：阿莫西林；热重分析；燃烧热；燃烧稳定性；
Abstract：
Amoxicillin were selected as the research objects, and the heat of combustion was measured by oxygen bomb calorimeter. The order of the heat of combustion of the four drugs was manufacturer 4 > manufacturer 3 > manufacturer 1 > manufacturer 2. The combustion heat of drug test samples was between 9 012. 70 - 20 370. 59 J·g - 1 , CV < 5% . From the results of thermogravimetric analysis, the order of combustion stability to the four drugs was manufacturer 2 > manufacturer 1 > manufacturer 3 > manufacturer 4. The drugs from different manufacturers were divided into three categories according to the entropy cluster analysis. A multi-index comprehensive evaluation system for four drugs was established, providing a strong scientific basis for the study of the combustion stability of drugs.
Keywords：Amoxiciuin; thermogravimetric analysis; heat of combustion; combustion stability;