【个人资料】

吴亚锋，教授，博导

东南大学化学化工学院

江苏靖江

联系邮箱：wuyafeng@seu.edu.cn

【研究方向】

功能化微纳通道的设计及生物分析应用，多功能纳米探针的制备及在肿瘤诊断与治疗中的应用

【经历】

2006.9 – 2012.3  博士，东南大学，应用化学专业，导师：刘松琴教授

2008.9 – 2009.9  联合培养博士，美国北卡罗来纳州立大学，

2012.4 – 2016.2  新加坡南洋理工大学，博士后，导师：康跃军教授

2016.3 – 2018.1  中国科学院理化技术研究所，博士后，导师：江雷院士

2018.1 – 2023.12东南大学化学化工学院，副研究员

2024.1 –至今    东南大学化学化工学院，教授

【科研项目】

1.国家自然科学基金委员会, 面上项目, 22374019, 基于纳通道技术的新型血脑屏障体外模型的构建及应用, 2024-2027, 50万元, 在研, 主持

2. 国家自然科学基金面上项目，22174016，脑胶质瘤单细胞多标志物同时检测新方法及异质性分析研究，2022.01-2025.12，58万元，主持。

3. 国家自然科学基金青年基金项目，基于DNA凝胶的仿生智能离子通道和离子泵的研究及应用，2018-2020，25万，主持

4. 东南大学-南京医科大学合作研究项目，基于纳米技术的miRNA检测与肝癌精准治疗研究，2017-2020，18万，主持

5. 中央高校基本科研专项资金，诊疗一体化纳米探针用于耐药肿瘤细胞表面p-糖蛋白的同时检测和抑制：体内和体外评估，2019-2020，5万，主持

【学术奖励】

2023年  第三届高校分析测试优秀青年人才奖

2022年  中国化学快报第四届青年编委会委员

2020年  中国化学会第十四届全国电分析化学学术会议优秀青年报告奖

2013年  江苏省优秀博士学位论文

2013年  东南大学优秀博士学位论文

【发表论文】

[1] Fengying Shao, Jianyu Han, Zhaoyan Tian, Zhi Wang, Songqin Liu, Yafeng Wu*. Synergistic ROS generation and directional overloading of endogenous calcium induce mitochondrial dysfunction in living cells. Biomaterials2023, 122284.

[2] Zhaoyan Tian, Xiang Qin, Fengying Shao, Xiuxiu Li, Zhi Wang, Songqin Liu, Yafeng Wu*. Electrofluorochromic imaging analysis of dopamine release from living PC12 cells with bipolar nanoelectrodes array. Chinese Chem. Lett.2023, 34, 107656.

[3] Jianyu Han, Songqin Liu, Zhi Wang, Yafeng Wu*. Micro/nanofluidic-electrochemical biosensors for in situ tumor cell analysis. Trends Anal. Chem.2022, 157, 116799.

[4] Xiuxiu Li, Xiang Qin, Yafeng Wu*, Kang Wang, Xinghua Xia, Songqin Liu*. Monitoring the electrochemical reactions on a gold nanoelectrode array via fluorescence-enabled electrochemical imaging. Chem. Commun.2022, 58, 12499.

[5] Xiuxiu Li, Xiang Qin, Zhaoyan Tian, Kang Wang, Xinghua Xia, Yafeng Wu*, Songqin Liu*. Gold nanowires array-based closed bipolar nanoelectrode system for electrochemiluminescence detection of α fetoprotein on cell surface. Anal. Chem.2022, 94, 7350-7357.

[6] Juan Su, Zhipeng Yao, Zixuan Chen, Sisi Zhou, Zhi Wang, Hongping Xia*, Songqin Liu*, Yafeng Wu*. TfR aptamer enhanced Blood-Brain Barrier penetration of biomimetic nanocomplexes for intracellular transglutaminase 2 imaging and silencing in glioma. Small2022, 2203448.

[7] Xiuxiu Li, Xiang Qin, Zhi Wang, Yafeng Wu*, Kang Wang, Xinghua Xia, and Songqin Liu*. In situ imaging of endogenous hydrogen peroxide efflux from living cells via bipolar gold nanoelectrode array and electrochemiluminescence technology. ACS Sens.2022, 7, 2446-2453.

[8] Zixuan Chen, Yafeng Wu*, Zhipeng Yao, Juan Su, Zhi Wang, Hongping Xia*, and Songqin Liu*. 2D Copper (II) Metalated Metal-Organic Framework nanocomplexes for dual-enhanced photodynamic therapy and amplified antitumor immunity. ACS Appl. Mater. Interfaces2022, 14, 44199-44210.

[9] Yafeng Wu, Zixuan Chen, Zhipeng Yao, Kaige Zhao, Fengying Shao, Juan Su, Songqin Liu*. Black phosphorus quantum dots encapsulated biodegradable hollow mesoporous MnO₂: dual-modality cancer imaging and synergistic chemo-phototherapy. Adv. Funct. Mater.2021, 31, 2104643.

[10] Sisi Zhou, Yao Yang*, Yafeng Wu*, Songqin Liu*. Multiplexed profiling of biomarkers in extracellular vesicles for cancer diagnosis and therapy monitoring. Anal. Chim. Acta2021, 1175, 338633.

[11] Fengying Shao, Yafeng Wu*, Zhaoyan Tian, Songqin Liu. Biomimetic Nanoreactor for Targeted Cancer Starvation Therapy and Cascade Amplificated Chemotherapy.Biomaterials 2021, 274, 120869.

[12] Zhaoyan Tian, Yafeng Wu*, Fengying Shao, Dezhi, Tang, Xiang Qin, Chenchen Wang, Songqin Liu*.Electrofluorochromic Imaging Analysis of Glycan Expression on Living Single Cell with Bipolar Electrode Arrays. Anal. Chem. 2021, 93, 5114-5122.

[13] Sisi Zhou, Tao Hu, Gaohua Han,Yafeng Wu,* Xin Hua, Juan Su, Weiwei Jin, Yiping Mou, Xiaozhou Mou, Quan Li, Songqin Liu. Accurate Cancer Diagnosis and Stage Monitoring Enabled by Comprehensive Profiling of Different Types of Exosomal Biomarkers: Surface Proteins and miRNAs. Small2020, 16, 2004492.

[14] Yafeng Wu, Yaqiong Gao, Juan Su, Zixuan Chen, Songqin Liu*. In situ detection of intracellular tissue transglutaminase based on aggregation-induced emission.Chem. Commun. 2020, 56, 9008-9011.

[15] Juan Su, Fubing Wu, Hongping Xia,* Yafeng Wu*, Songqin Liu*. Accurate cancer cell identification and microRNA silencing induced therapy using tailored DNA tetrahedron nanostructures. Chem. Sci. 2020, 11, 80-86.

[16] Sisi Zhou, Tao Hu, Feng Zhang, Dezhi Tang, Dake Li*, Jian Cao, Wei Wei, Yafeng Wu*, Songqin Liu*. Integrated Microfluidic Device for Accurate Extracellular Vesicle Quantification and Protein Markers Analysis Directly from Human Whole Blood. Anal. Chem.2020, 92, 1574-1581.

[17] Yafeng Wu, Guang Yang, Mingchang Lin, Xiangyu Kong, Li Mi, Songqin Liu, Guosong Chen,* Ye Tian,* Lei Jiang. Continuously tunable ion rectification and conductance in submicro-channel stemming from thermoresponsive polymer self-assembly. Angew. Chem. Int. Ed. 2019, 58, 1-6.

[18] Yafeng Wu, Fen Zhang, Kan Wang, Peicheng Luo, Yuanqing Wei, Songqin Liu*. Activatable Fluorescence Imaging and Targeted Drug Delivery via Extracellular Vesicle-Like Porous Coordination Polymer Nanoparticles. Anal. Chem.2019, 91, 14036-14042.

[19] Yuanqing Wei, Hongping Xia, Fen Zhang, Kan Wang, Peicheng Luo, Yafeng Wu*, Songqin Liu. Theranostic Nanoprobe Mediated Simultaneous Monitoring and Inhibition of P-Glycoprotein Potentiating Multidrug-Resistant Cancer Therapy. Anal. Chem.2019, 91, 11200-11208.

[20] Li Mi, Jing Sui, Yafeng Wu*, Geyu Liang, Yuanjian Zhang, Yuepu Pu, Ye Tian*, Songqin Liu*, Lei Jiang. Bioinspired in vitro lung airway model for inflammatory analysis via hydrophobic nanochannel membrane with joint three-phase interface. Anal. Chem.2019, 91, 15804-15810.

[21] Zhaoyan Tian, Li Mi,Yafeng Wu*, Fengying Shao, Mingqiang Zou, Zhenxian Zhou, and Songqin Liu*. Visual Electrofluorochromic Detection of Cancer Cell Surface Glycoprotein on a Closed Bipolar Electrode Chip. Anal. Chem.2019, 91, 7902-7910.

[22] Cheng Zheng, Xueying Qiu, Jianyu Han*, Yafeng Wu*, Songqin Liu. Zero-Dimensional-g-CNQD-Coordinated Two-Dimensional Porphyrin MOF Hybrids for Boosting Photocatalytic CO₂ Reduction. ACS Appl. Mater. Interfaces 2019, 11, 42243-42249.

[23] Yaqiong Gao, Yafeng Wu*, Kaige Zhao, Huaisheng Wang, Songqin Liu. In-Situ imaging detection of cell membrane and intracellular cholesterol via cascade reactions. Biosens. Bioelectron. 2019, 126, 249-254.

[24] Kaige Zhao, Min Tang, Huaisheng Wang, Zhenxian Zhou, Yafeng Wu*, Songqin Liu*. Simultaneous detection of three biomarkers related to acute myocardial infarction based on immunosensing biochip. Biosens. Bioelectron. 2019, 126, 767-772.

[25]Yafeng Wu, Dianyu Wang, Itamar Willner*, Ye Tian*, Lei Jiang*. Smart DNA Hydrogel Integrated Nanochannels with High Ion Flux and Adjustable Selective Ionic Transport. Angew. Chem. Int. Ed.2018, 57, 7790-7794.

[26] Jianyu Han^§, Hongping Xia^§, Yafeng Wu^§ (co-first author), Shik Nie Kong, Amudha Deivasigamani, Rong Xu*, Kam M. Hui*, Yuejun Kang*. Single-layer MoS₂ nanosheet grafted upconversion nanoparticles for near-infrared fluorescence imaging-guided deep tissue cancer phototherapy. Nanoscale 2016, 8, 7861-7865.

[27]Yafeng Wu, Jianyu Han, Peng Xue, Rong Xu, Yuejun Kang*. Nano Metal-Organic Framework (NMOF)-Based Strategies for Multiplexed MicroRNA Detection in Solution and Living Cancer Cells. Nanoscale 2015, 7, 1753-1759.

[28] Yafeng Wu, Peng Xue, Kam M. Hui*, Yuejun Kang*. A paper-based microfluidic electrochemical immunodevice integrated with amplification-by-polymerization for the ultrasensitive multiplexed detection of cancer biomarkers. Biosens. Bioelectron.2014, 52, 180-187.

[29] Yafeng Wu, Peng Xue, Kam M. Hui*, Yuejun Kang*. Electrochemical- and Fluorescent-Mediated Signal Amplifications for Rapid Detection of Low-Abundance Circulating Tumor Cells on a Paper-Based Microfluidic Immunodevice. ChemElectroChem2014, 1, 722-727.

[30] Yafeng Wu, Peng Xue, Yuejun Kang*, Kam M. Hui*. Paper-Based Microfluidic Electrochemical Immunodevice Integrated with Nanobioprobes onto Graphene Film for Ultrasensitive Multiplexed Detection of Cancer Biomarkers. Anal. Chem.2013, 85, 8661-8668.

[31] Yafeng Wu, Peng Xue, Yuejun Kang*, Kam M. Hui*. Highly Specific and Ultrasensitive Graphene-Enhanced Electrochemical Detection of Low-Abundance Tumor Cells Using Silica Nanoparticles Coated with Antibody-Conjugated Quantum Dots. Anal. Chem.2013, 85, 3166-3173.

[32] Yafeng Wu, Songqin Liu*. Target-triggered polymerization for biosensing. Accounts Chem. Res. 2012, 45, 1441-1450.

[33] Yafeng Wu, Hao Zhou, Wei Wei, Xin Hua, Lixin Wang, Zhenxian Zhou, Songqin Liu*, Signal Amplification Cytosensor for Evaluation of Drug-Induced Cancer Cell Apoptosis. Anal. Chem.2012, 84, 1894-1899.

[34]Yafeng Wu, Songqin Liu*, Lin He, Polymerization-assisted signal amplification for electrochemical detection of biomarkers. Analyst2011, 136, 2558-2563.

[35] Yafeng Wu, Songqin Liu*, Lin He, Activators Generated Electron Transfer for Atom Transfer Radical Polymerization for Immunosensing. Biosens. Bioelectron.2010, 26, 970-975.

[36] Yafeng Wu, Hongyan Shi, Liang Yuan, Songqin Liu*, A novel electrochemiluminescence immunosensor via polymerization-assisted amplification. Chem. Commun.2010, 46, 7763-7765.

[37] Yafeng Wu, Songqin Liu*, Lin He*, Electrochemical biosensing using amplification-by-polymerization. Anal. Chem.2009, 81, 7015-7021.

[38] Yafeng Wu, Chengliang Chen, Songqin Liu*, Enzyme-Functionalized Silica Nanoparticles As Sensitive Labels in Biosensing. Anal. Chem.2009, 81, 1600-1607.

[39] Yafeng Wu, Songqin Liu*, Immunosensing system for ɑ-fetoprotein through boronate immunoaffinity column in combination with flow injection chemiluminescence. Analyst2009, 134, 230-235.

[40] Yafeng Wu, Yafeng Zhuang, Songqin Liu*, Lin He, Phenylboronic acid immunoaffinity reactor coupled with flow injection chemiluminescence for determination of α-fetoprotein. Anal. Chim. Acta2008, 630, 186-193.