周雯 硕士生导师 化学化工学院
办公地点：东南大学九龙湖校区新化工路411
联系电话：15261879380
研究方向：药物化学与化学生物学
主持科研基金项目：
1.国家自然科学基金：缺氧促发型碳酸酐酶9抑制剂的设计合成及其抗心肌缺氧损伤研究，22207016，30万，2023.1–2025.12.
2.江苏省自然科学基金：线粒体靶向性琥珀酸脱氢酶抑制剂的分子设计与抗心肌缺血再灌注损伤研究，BK20180570，20万，2018.7–2021.12.
近五年主要论文：
1. Wen Zhou, Keyu Fan, Wuyang Hua, Shaohua Gou*. A hypoxia-activated NO donor for the treatment of myocardial hypoxia injury. Chemical Science, 2022, 13, 3549. (IF=9.969)
2. Wen Zhou, Chunping Wang, Keyu Fan, Zhikun Liu, Shaohua Gou*. Hypoxia-activated prodrugs with dual COX-2/CA inhibitory effects on attenuating cardiac inflammation under hypoxia. Journal of Medicinal Chemistry, 2022, 65, 13436. (IF=8.039)
3. Wen Zhou, Keyu Fan, Xiaojian Yin, Yuxuan Wang, Shaohua Gou*. A tanshinone IIA derivative designed to target mitochondria inhibit myocardial ischemia/reperfusion injury in vivo in a GUF1 dependent-pathway. Pharmacological Research–Modern Chinese Medicine. 2022, 2, 100066.
4. Bin Zhang#, Zichen Xu#, Wen Zhou, Zhikun Liu, Jian Zhao, Shaohua Gou*. A light-controlled multi-step drug release nanosystem targeting tumor hypoxia for synergistic cancer therapy. Chemical Science. 2021, 12, 11810. (IF=9.969)
5. Wen Zhou, Bin Zhang, Keyu Fan, Xiaojian Yin, jinfeng Liu, Shaohua Gou*. An original aspirin-containing carbonic anhydrase 9 inhibitor overcomes hypoxia-induced drug resistance to enhance the efficacy of myocardial protection. Cardiovascular Drugs and Therapy. 2021, 36, 605. (IF=3.947)
6. 乙酰唑胺衍生物及其制备方法和在制备治疗冠心病药物中的应用。苟少华，周雯，张斌。CN111961043A，2020.11.（发明专利）
7. Fei Wang, Qingqing Peng, Jingfeng Liu, R.N. Alolga, Wen Zhou*. A novel ferulic acid derivative attenuates myocardial cell hypoxia reoxygenation injury through a succinate dehydrogenase dependent antioxidant mechanism. European Journal of Pharmacology, 2019, 856, 172417. (IF=5.195)
8. Yunpeng Zhao, Fei Wang, Wei Jiang, Jinfeng Liu, Baolin Liu, Lianwen Qi, Wen Zhou*. A mitochondrion-targeting tanshinone IIA derivative attenuates myocardial hypoxia reoxygenation injury through a SDH-dependent antioxidant mechanism. Journal of Drug Targeting, 2019, 11, 1. (IF=5.016)
9. Lanzhu Li, Guoxiu Zhou, Jia Li, Wei Jiang, Baolin Liu, Wen Zhou*. Compounds containing trace element copper or zinc exhibit as potent hyperuricemia inhibitors via xanthine oxidase inactivation. Journal of Trace Elements in Medicine and Biology, 2018, 49, 72. (IF=4.001)
